• Tamoxifen: Multifaceted Mechanisms Beyond Estrogen Recept...

  2025-09-22

  Explore the complex roles of Tamoxifen as a selective estrogen receptor modulator in breast cancer research, kinase inhibition, gene knockout studies, and emerging antiviral applications. This article details novel mechanistic insights, including autophagy induction and heat shock protein 90 activation.

• Tamoxifen: Expanding Roles in Kinase Inhibition and Immun...

  2025-09-19

  This article explores the advanced mechanisms by which tamoxifen, a selective estrogen receptor modulator, modulates protein k

• Tamoxifen: Multifaceted Tool in Molecular Biology and Ant...

  2025-09-18

  Explore the diverse applications of Tamoxifen, a selective estrogen receptor modulator, in genetic engineering, cancer biology, and antiviral studies. This article highlights mechanistic insights and advanced uses of Tamoxifen in contemporary research.

• Mitochondria from frozen thawed bull sperm are capable of pr

  2025-03-03

  

  Mitochondria from frozen-thawed bull sperm are capable of producing energy using pyruvate and lactate as substrates through oxidative pathways (Beorlegui et al., 1997). Based on the present study, heparin capacitated sperm had a lesser lactate concentration in the incubation medium, supporting the h

• Oxidative stress has recently been reported as one

  2025-03-03

  

  Oxidative stress has recently been reported as one of the important mechanisms of toxic effect of Cd2+[43]. The mechanism of Cd2+-induced oxidative stress involves an imbalance between generation and removal of ROS in tissues and cellular components, causing damage to membranes, DNA, and proteins [4

• The first rationally designed dual

  2025-03-03

  

  The first rationally designed dual mPGES-1/5-LO inhibitor was reported in 2008 and represents a structural derivative of pirinixic Nitrocefin β-lactamase detection - a synthetic agonist of PPARα with lipid-lowering properties (Koeberle et al., 2008b). Further α-alkyl- and α-aryl-substituted derivat

• br Materials and Methods br Author

  2025-03-03

  

  Materials and Methods Author Contributions Conflicts of Interest Acknowledgments This study was funded by the NIH Common Fund (UH2TR000943) through the Office of Strategic Coordination/Office of the NIH Director, an NCI/NIH grant (1R21CA199050), the MD Anderson Cancer Center support gran

• Estrogen exerts its genomic action via

  2025-03-01

  

  Estrogen exerts its genomic action via Sobetirome nuclear receptor: ERα and ERβ. The distribution of ERα and/or ERβ positive neurons in CNS of different species has been mapped extensively by various methods [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], although there are some differe

• gpr55 agonist Luo Dehm Raj Luo Attard Balk Bevan Burnstein C

  2025-03-01

  

  Luo, Dehm, Raj. Luo, Attard, Balk, Bevan, Burnstein, Cato, Cherkasov, De Bono, Dong, Gao, Gleave, Heemers, Kanayama, Kittler, Lang, Lee, Logothetis, Matusik, Plymate, Sawyers, Selth, Soule, Tilley, Weigel, Zoubeidi, Dehm, Raj. Luo, Attard, Balk, Bevan, Burnstein, Cato, Cherkasov, De Bono, Dong,

• br Materials and methods br Results br Discussion Endophilin

  2025-03-01

  

  Materials and methods Results Discussion Endophilin A1 is a membrane-binding protein that is mainly distributed in the central nervous system (Giachino et al., 1997), localizes in the dendritic shafts and spines of mature neurons (Yang et al., 2015), and relates to the function and morpholo

• An important and well documented pathway involved in cellula

  2025-03-01

  

  An important and well-documented pathway involved in cellular growth and proliferation is the mTOR-mediated synthesis of proteins and lipids [7,13,14]. Although found to be tissue specific or context specific regulation, it has always been observed that either one or both the mTOR complexes regulate

• In summary this study reveals that the stability of rapsyn

  2025-03-01

  

  In summary, this study reveals that the stability of rapsyn is critically dependent on HSP90β, highlighting a novel function of HSP90β in NMJ formation and maintenance. It also identifies a mechanism in agrin signaling for AChR clustering, i.e., by upregulating the interaction between HSP90β and rap

• This raises an important question May the

  2025-03-01

  

  This raises an important question: May the lack of ethnolinguistic theories and of explicit references to language be related to the lack of contact with other groups and their languages? For the past few centuries at least, the Aché seem to have been culturally and linguistically isolated (Hill and

• FSLLRY-NH2 While the direct effects of ARI lead

  2025-02-28

  

  While the direct effects of 5-ARI lead to a dramatic FSLLRY-NH2 in serum DHT levels, other laboratory values are also affected by 5-ARI use. Serum testosterone elevations are known to occur with both finasteride and dutasteride use, but values will typically remain within the normal laboratory range

• br Results br Discussion Our finding that AXL

  2025-02-28

  

  Results Discussion Our finding that AXL overexpression is significantly associated with poor survival in patients with high-grade serous OC is consistent with previous reports indicating that AXL regulates tumor growth in some cancers, as well as reports showing that AXL activity is involved i

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