• Needless to say FA must enter into

  2020-07-29

  

  Needless to say, FA must enter into the cell in order to be metabolized. One of the proteins involved in FA uptake is FAT/CD36, an integral membrane glycoprotein which has been found in a wide variety of cells (Abumrad et al., 1993, Coburn et al., 2000, Bonen et al., 2004). Once FA are incorporated

• Alternative splicing is a critical part of

  2020-07-29

  

  Alternative splicing is a critical part of regulating gene expression; over 90% of the human transcriptome is alternatively spliced [4]. Identifying the role of alternative splicing in the function of multiple biological and disease processes has driven many research initiatives in recent years [5].

• D dopamine receptors are mostly expressed in the

  2020-07-28

  

  D5 dopamine receptors are mostly expressed in the thalamus, hippocampus, and on the dopaminergic neurons in the ventral tegmental area (Ciliax et al., 2000). The role of these receptors in the selinexor is not completely determined. However, D5 receptors may participate in emotion regulation, memor

• DNA PK is a heterotrimeric complex consisting of the catalyt

  2020-07-28

  

  DNA-PK is a heterotrimeric complex consisting of the catalytic subunit DNA-PKcs and a heterodimer of Ku70 and Ku80. DNA-PK binds dsDNA breaks and functions in non-homologous end joining (NHEJ) (Pannunzio et al., 2018) and also in DNA sensing, upregulating type I IFN and cytokines via the STING pathw

• Since the initial identification of DNA ligase inhibitors by

  2020-07-28

  

  Since the initial identification of DNA ligase inhibitors by a structure-based approach [[18], [26]], there have been several reports describing LigI inhibitors using computer modelling and derivatives of the original DNA ligase inhibitors [[49], [50], [51]]. While these studies have shown that the

• The promoter region of the detoxifying gene GSTP

  2020-07-28

  

  The promoter region of the detoxifying gene, GSTP1, is commonly hypermethylated in the promoter region in prostate adenocarcinoma and hepatocellular carcinoma,38, 39 but it was not hypermethylated in either oral cancer tissue, adjacent mucosa, or normal oral mucosa, as previously reported. The regul

• br Conclusion br Conflict of interest br Prostaglandin D PGD

  2020-07-28

  

  Conclusion Conflict of interest Prostaglandin D2 (PGD) is the major prostanoid released by mast cells during allergic attacks., In human patients, allergen challenge leads to a rapid increase in the production of PGD in the airway of asthmatics, in the nasal mucosa of allergic rhinitics and

• According to Graeff Graeff innate fear

  2020-07-28

  

  According to Graeff (Graeff, 1990), innate fear is mediated by neural circuitry that consists of at least the amygdala, medial hypothalamus and periaqueductal grey matter. In particular, the BLA has been considered to be a structure closely related to emotional responses to fear, stress and anxiety

• The dilute gas viscosity is defined as

  2020-07-28

  

  The dilute gas viscosity (ηο) is defined as the viscosity zero density limit and to the kinetic theory of gases [19] and is related to Chapman–Enskog theory [5], [19], [20]. Based on Chapman–Enskog theory and empirical estrone for the reduced collision integral, Chung et al. [21] did an empirical d

• br Conclusions In this study

  2020-07-28

  

  Conclusions In this study, we identified and characterized seventeen members of the CLC gene family in tobacco. A phylogenetic analysis indicated that the NtCLC genes were divided into two clades, as was reported for other plant species. The results of our gene structure and conserved motif analy

• br STAR Methods br Author Contributions br

  2020-07-27

  

  STAR★Methods Author Contributions Acknowledgments The authors thank Monika Kuhn for excellent technical assistance and Dr. Antje Schäfer for valuable scientific input. H.S. was supported by the DFG (FZ 82; Graduate School of Life Sciences and SCHI 425-6/1), and A.V.S. by Northwestern Univer

• SFN has been shown to

  2020-07-27

  

  SFN has been shown to trigger apoptosis through downregulation of EGFR protein (Mondal et al., 2016). We have recently shown that SFN inhibits EGFR signaling by promoting proteasome-mediated degradation of EGFR in NSCLC (Chen et al., 2015). High-level induction of ROS has been shown to trigger the

• br Experimental Procedures br Author Contributions br Acknow

  2020-07-27

  

  Experimental Procedures Author Contributions Acknowledgments Introduction Germinal centers (GCs) form in secondary lymphoid organs of vertebrates in response to challenge with T-cell-dependent antigens. After extrafollicular and follicular interactions with cognate antigen and T helper c

• ras inhibitor The pharmacodynamic potential of compound was

  2020-07-27

  

  The pharmacodynamic potential of ras inhibitor 52 was initially evaluated in an oral triglyceride tolerance test. C57BL/6 mice were treated with vehicle, 0.1, 0.3 or 1mg/kg of 52 30min prior to dosing with a corn oil bolus. Plasma triglyceride (TG) levels were monitored every hour over the course o

• RWJ 56110 Industrial fermentation aims to produce valuable p

  2020-07-27

  

  Industrial fermentation aims to produce valuable products from cheap feedstocks by utilizing diverse microbial functions through aerobic or anaerobic fermentation [[8], [9], [10]]. During anaerobic fermentation, the reducing power is mostly directed to product synthesis rather than being oxidized, r

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