• A high fat maternal diet during the pregestation period and

  2022-03-03

  

  A high-fat maternal diet during the pregestation period and extending throughout gestation (including the period of conception) has the propensity of affecting early embryonic development and placentation. Previous investigations have revealed that the preimplantation embryos are generally exposed t

• Urolithin A Genetic disruption or pharmacologic inhibition o

  2022-03-02

  

  Genetic disruption or pharmacologic inhibition of the hepatic glucagon pathway has invariably been shown to increase pancreatic α cell mass. This has been observed in glucagon receptor (GCGR) knockout (Gcgr−/−) mice (Gelling et al., 2003), glucagon knockout mice (Hayashi et al., 2009), prohormone co

• Although in in vitro analyses GANT sensitized Daoy

  2022-03-02

  

  Although in in vitro analyses GANT61 sensitized Daoy testes of to RITA treatment, this was not fully reflected in the in vivo xenograft studies in nude mice, as the combinatorial treatment elicited a comparable reduction of tumor growth. However, the dual drug administration reduced within-group va

• Despite a robust impact on learned social feeding behaviors

  2022-03-02

  

  Despite a robust impact on learned, social feeding behaviors, we observed no differences in body weight or food intake when the control or vHP GHSR-1A KD animals were maintained on either a normal chow diet or a Western diet high in fat and sugar. This is interesting in light of our previous work sh

• br Acknowledgement This work was supported by National Scien

  2022-03-02

  

  Acknowledgement This work was supported by National Science Foundation (21475047, 21705051, 21874048), the Science and Technology Planning Project of Guangdong Province (2016B030303010), the Program for the Top Young Innovative Talents of Guangdong Province (2016TQ03N305) and the Foundation for H

• Recently accumulated evidence has revealed a

  2022-03-02

  

  Recently, accumulated evidence has revealed a close link of FXR to gluconeogenesis. For example, activation of FXR by its agonist GW4064 improved hyperglycemia in db/db mice by repressing gluconeogenesis [15], and FXR agonist CDCA decreased transactivation activity of key gluconeogenic genes by indu

• The release of FBPase and aldolase

  2022-03-02

  

  The release of FBPase and aldolase from subcellular structures of muscle was dependent on the presence of the crowding agent imitating the physiological conditions – PEG 8000 (Table 1). The amount of both enzymes associated with structures of muscle Fesoterodine Fumarate was about 6–7 times higher

• During the activation of the coagulation

  2022-03-02

  

  During the activation of the coagulation cascade, factor Xa (FXa) forms a complex with activated factor V and calcium heme oxygenase on the surface of platelet membrane (so called prothrombinase complex) and converts prothrombin to thrombin [5], [6]. Selective FXa inhibitors do not directly inhibit

• In the present study LLY suppressed

  2022-03-02

  

  In the present study, LLY-507 suppressed the proliferation of HGSOC NPI-0052 australia via induction of apoptosis. Moreover, the colony-formation assay showed the long-term effects of SMYD2 inhibitors on HGSOC. It has been reported that LLY-507 induces an anti-tumor effect in several types of cance

• Before discovery of their histone

  2022-03-02

  

  Before discovery of their histone demethylase function, the JARID1 isoforms were identified across diverse fields including stem cell biology and congenital disease, as detailed in Box 2. Their observed roles in cancer progression and therapy resistance have led to ongoing pursuit of inhibitors tail

• br Materials and methods br Results br Discussion Several hi

  2022-03-02

  

  Materials and methods Results Discussion Several histamine H3 receptor antagonists have progressed into clinical development for indications including Alzheimer's disease, schizophrenia, pain and narcolepsy. Each of the compounds studied herein has been extensively characterized in its own

• br Materials and methods br Results

  2022-03-02

  

  Materials and methods Results Discussion Numerous studies have identified important roles for HIF-1α in cellular function and dysfunction through its transcriptional activity [4]. A few studies have reported that HIF-1α is translocated to the mitochondria in human and mouse cancer cell line

• Heme activates the master regulator of the

  2022-03-02

  

  Heme activates the master regulator of the anti-oxidant stress response, NRF2, which mediates the up-regulation of a battery of phase II detoxifying genes [106]. Remarkably, HO-1 induction by NRF2 is regulated via an interplay with the transcriptional repressor BACH1 at the Maf recognition 1661010

• Curcumin is a major yellow

  2022-03-01

  

  Curcumin is a major yellow pigment in turmeric ground rhizome of Curcuma longa Linn, which is used widely as a spice and coloring agent in several foods such as curry, mustard and potato chips as well as cosmetics and drugs (Okada et al., 2001, Joe et al., 2004). Curcumin represents a class of anti-

• br Activity dependent control of myelination and myelin main

  2022-03-01

  

  Activity-dependent control of myelination and myelin maintenance Oligodendrocytes have intrinsic myelinating capacity and can myelinate fixed CAY10603 synthesis in addition to synthetic nanofibers and micropillars [21, 34, 35]. What prevents oligodendrocytes from myelinating dendrites or other c

14445 records 443/963 page Previous Next First page 上5页 441442443444445 下5页 Last page