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HTH-01-015 Luciferase Immunoprecipitation Systems LIPS which
2024-12-17
Luciferase Immunoprecipitation Systems (LIPS), which utilizes recombinant antigens fused to the enzyme reporter Renilla luciferase (Ruc) to detect patient antibodies, provides a unique platform to investigate HTH-01-015 directed against a variety of antigenic targets [25]. Previously, LIPS has been
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An alternative to the agonist or antagonist potential in dru
2024-12-17
An alternative to the agonist or antagonist potential in drug discovery is the positive allosteric modulator (PAM) approach, which can augment the normal processes of neurotransmission as opposed to directly replacing or antagonizing them. PAMs are thought to bind to sites that are distinct from the
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In order to determine whether
2024-12-16
In order to determine whether the faster Rh2-induced apoptosis is specific of cholesterol depletion, we determined the cytotoxic effect of Rh2 in phosphodiesterase inhibitors depleted or not in sphingomyelin, another abundant plasma membrane lipid exhibiting enrichment in lipid rafts. We showed tha
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Serum concentrations of APP and antioxidants of
2024-12-16
Serum concentrations of APP and antioxidants of the 10 queens with pyometra before surgery (T0), at day two (T1) and at day 10 (T2) after ovariohysterectomy are presented in Fig. 1. Concentrations of SAA and Hp were significantly lower (P Discussion Acute phase protein responses were already desc
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Bamboo shoots with their high nutritive http www apexbt com
2024-12-16
Bamboo shoots, with their high nutritive and therapeutic value, are now used for food fortification (Nirmala & Bisht, 2017). Several value-added products such as nuggets, crackers, chutney, snacks, cookies, cakes, chappaties, and buns have been prepared from bamboo shoots (Table 3). Dietary fiber fr
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Introduction Alzheimer s disease AD is a
2024-12-16
Introduction Alzheimer's disease (AD) is a complex neurological disorder characterized by a progressive dementia resulting from synapse failure (Selkoe, 2002, Tanzi, 2005). The amyloid hypothesis maintains that the pivotal event in AD is the production of amyloid-β (Aβ) peptides following the prote
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The current guidelines are designed to optimize the detectio
2024-12-16
The current guidelines are designed to optimize the detection of IHC+FISH+ cases, most of which (but not all encountered in our study) being classically good responders to crizotinib therapy (resistance mechanisms to crizotinib therapy were not investigated in our study). In addition to the current
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As one of emerging high throughout methods metabolomics dete
2024-12-16
As one of emerging high-throughout methods, metabolomics detects metabolites which are ultimate response of biological systems to environmental changes [14]. Metabolomics uncovers metabolic alteration at the systems level. Comparison of global metabolic profiling reflects some unidentified biologica
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In the previous study we demonstrated
2024-12-16
In the previous study, we demonstrated the importance of the mPFC postsynaptic 5-HT1A receptor in the sustained antidepressant effects, because a sustained antidepressant effect was obtained with intra-mPFC injection, but not systemic injection of 8-OH-DPAT, a 5-HT1A receptor agonist (Fukumoto et al
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Specifically equity injections in a multinational affiliate
2024-12-13
Specifically, equity injections in a multinational affiliate X located in an ACE country can be passed on as lending to another group member Y located in a different country with a high corporate income tax rate. For the group member Y, the interest on the loans is tax deductible, and at the same ti
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Introduction Dementia is a common disease in
2024-12-13
Introduction Dementia is a common disease in the elderly, and a significant source of disability, healthcare spending, and long-term care admissions. There is evidence to suggest that testosterone plays a role in cognitive functioning, and lower serum levels correlate with higher amyloid deposits (
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evofosfamide mg Previously we reported that EL Kras mice fed
2024-12-13
Previously, we reported that EL-Kras mice-fed diets rich in omega-6 FAs demonstrated increased pancreatic mast cell infiltration [16]. Significantly, increased infiltration of mast cells into the tumor microenvironment correlates with a poor prognosis [15]. Soucek et al.[25] demonstrated that mast c
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br Conflict of interest br Acknowledgments br Introduction I
2024-12-13
Conflict of interest Acknowledgments Introduction Inflammation is a protective response of the microcirculation to harmful stimuli. Yet, excessive inflammation is potentially harmful and a characteristic of many chronic diseases [1]. 5-Lipoxygenase (5-LO, EC1.13.11.34) contributes to the in
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In summary the role of
2024-12-13
In summary, the role of 5-HT and different types of 5-HTRs in gating plasticity induction in neocortical circuits remains unclear, with variable and seemingly contradictory effects reported for LTP induction in cortical sensory fields (e.g., V1, enhanced LTP: Inaba et al., 2009, Kojic et al., 1997,
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The present study indicates elevated ATX activity as a
2024-12-13
The present study indicates elevated ATX activity as a highly sensitive and specific biomarker to differentiate ICP from other pregnancy-related liver disorders or pruritic dermatoses. In 3CAI sale to the current gold standard for diagnosis, total fasting serum bile salt levels, ATX appeared as a v