• Tourette s syndrome TS is a

  2022-07-02

  

  Tourette's syndrome (TS) is a neurobehavioral disorder characterized by chronic motor and vocal tics. The histaminergic system appears to be implicated in the pathophysiology of TS because H3R up-regulation has been observed in the striatum of HDC knock-out animal models (Rapanelli et al., 2017; Rap

• br Conflict of interest br Acknowledgments We

  2022-07-01

  

  Conflict of interest Acknowledgments We thank Professor Chen Rui (Southeast University, China) for providing plasmid P1P2N-HIF1. This study was supported by research grants from National Natural Science Foundation of China (81573189, 81730087). Introduction The consumption of large amounts

• Among the isoforms of heme

  2022-07-01

  

  Among the 3 isoforms of heme oxygenases (HO-1, HO-2, and HO-3), HO-1 expression is inducible, and it catalyzes the degradation of heme to biliverdin, carbon monoxide (CO) and free Fe. The Fe is then stored in ferritin, limiting its ability to participate as a catalyst through the Fenton reaction and

• The first wave of cells infiltrating heart shortly

  2022-07-01

  

  The first wave of Fluorescein-12-dUTP infiltrating heart shortly after MI is composed mainly of neutrophils, with the highest number on the first day after ischemic episode [101]. These cells are recruited via C-X-C motif chemokine ligand-2 (CXCL-2)- and CXCL-5-mediated chemotaxis. Both chemokines

• In this new therapeutic era nucleic acid amplification tests

  2022-07-01

  

  In this new therapeutic era, nucleic sc9 amplification tests (NAATs) remain critically useful. NAATs are recommended to detect HCV RNA in blood following initial serologic diagnosis of HCV infection, to distinguish between spontaneous resolution and progression to chronic infection [7]. In treatmen

• br Materials and methods br Results br

  2022-07-01

  

  Materials and methods Results Discussion An HMC is a blinding type of cataract frequently observed in Asian countries due to the appallingly high incidence of high myopia in those areas [4], [5] and typically features earlier onset and more rapid progression of nuclear cataract [1], [2]. Th

• IC is a rat mAb specifically binding

  2022-07-01

  

  IC2 is a rat mAb specifically binding to insulin granula [127,128]. Although this mAb was discovered 30 years ago, it has only recently been used for β-cell imaging in vivo. Moore et al. used this mAb for β-cell imaging in 2001 [129]. After DTPA conjugation, IC2 was labeled with 111In. Both in vitro

• The differential tissue and ligand dependent signaling descr

  2022-07-01

  

  The differential tissue- and ligand-dependent signaling described here has important implications for the therapeutic potential of synthetic GPR109A agonists for the treatment of atherosclerosis. The failure of MK-0354, a biased, partial GPR109A agonist, to activate signaling pathways upstream of va

• br Material and methods br Results br

  2022-07-01

  

  Material and methods Results Discussion Neurosteroids capable of blocking the NMDAR channel attract a lot of attention as possible therapeutic agents for the treatment of neurodegenerative diseases. A large number of new PTC209 HBr with different structures have been synthesized in order t

• br Genetic rescue of GluR A dependent

  2022-07-01

  

  Genetic rescue of GluR-A-dependent spatial working memory Spatial working memory performance in GluR-A−/− mice can be restored by the forebrain-specific Ezetimibe synthesis of GluR-A subunits labeled with green-fluorescent protein (GFP) on an otherwise GluR-A knockout background (Schmitt et al.,

• br Methods br Results br Discussion Among

  2022-07-01

  

  Methods Results Discussion Among three main signaling pathways activated by bFGF, the MAPK pathway was found to be involved in the upregulation of GR levels. So far, there have been a few candidates that could connect activated ERK to the upregulation of GR. One likely candidate is the zinc

• br Results br Discussion ER and GR play opposite

  2022-07-01

  

  Results Discussion ER and GR play opposite phenotypic roles in the normal endometrium, with ER promoting growth and GR inhibiting growth. Here, we show that in endometrial cancer, GR expression is associated with worse outcomes and higher-grade tumors, and this association is observed only in

• br Regulation of the GLI code

  2022-07-01

  

  Regulation of the GLI code by non-HH signals and by the oncogenic load The GLI code may be seen as the essential parameter to regulate canonical HH output. Its regulation first appeared to be strictly dependent on the presence of specific levels of HH ligands. Indeed, GLI1 transcription is so far

• br Materials and methods br Transparency document br Acknowl

  2022-07-01

  

  Materials and methods Transparency document Acknowledgments Introduction Hearing loss is the most common congenital sensory deficit. About 1–3 in 1000 children are affected at birth or during early childhood by severe hearing loss, which is defined as prelingual deafness, with at least h

• A relatively independent review of the

  2022-06-30

  

  A relatively independent review of the history of the discovery of GABA (and L-glutamate) as neurotransmitters in the CNS can be found in ‘When and why amino acids?’ in the in 2010 by Kresimir Krnjevic , who spent a post-doc in Canberra in 1956–1958. Introduction The insect RDL GABA receptor is

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