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Introduction Epigenetic mechanisms modulate heritable phenot
2022-08-22
Introduction Epigenetic mechanisms modulate heritable phenotypic changes that are not dictated by changes in DNA sequences. The link between epigenetic modifications and cancer development has been established [1], [2]. Histone modifications represent an important class of epigenetic mechanisms tha
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br Soluble guanylyl cyclase nitric oxide and
2022-08-22
Soluble guanylyl cyclase, nitric oxide and nitric oxide synthase The primary and best-studied endogenous activator of soluble guanylyl cyclase (sGC) is nitric oxide (NO), which was originally describe as endothelium-derived relaxing factor for its potent ability to relax blood vessels in response
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br Conclusions and future perspectives br Declarations of in
2022-08-22
Conclusions and future perspectives Declarations of interest Acknowledgements The authors thank Mrs. Kamala Pandey for the help in the preparation of this manuscript. This work was supported by NIH grants R01HL057531 and R01HL062147. Introduction Separation of short exons by long non-co
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br Molecular mechanisms underpinning GSNOR function in
2022-08-22
Molecular mechanisms underpinning GSNOR1 function in the defence response Recently, Arabidopsis GSNOR1 has been shown to govern the extent of S-nitrosylation of two key regulatory proteins, Non-Expresser of Pathogenesis-Related Genes 1 (NPR1) and SA binding protein 3 (SABP3), which are integral t
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Preliminary analyses of these identified two bands for
2022-08-22
Preliminary analyses of these identified two bands for MALDI-TOF/TOF have shown the presence of approximately 20 proteins, most of which have not yet been characterized. However, several proteins, such as cytochrome c oxidase [53], peroxiredoin II E [54] and alcohol dehydrogenase [55], have been ide
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Considering that loss of LAG expression results in increased
2022-08-22
Considering that loss of LAG-3 CD 2665 results in increased CD4+ T cell homeostatic expansion, and that the ability of a cell to proliferate is tightly coupled to its metabolic profile, we hypothesized that LAG-3 regulates naive CD4+ T cell metabolism. Our results indicate that, indeed, Lag3-defici
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Among the compounds prepared at this stage the cyclopropylme
2022-08-22
Among the compounds prepared at this stage, the cyclopropylmethylenoxy analogue attracted our most attention since it demonstrated particularly good in vitro potency at GlyT1 (16nM), no activity at the GlyT2 isoform up to the highest concentration tested (30μM), good physical properties with modera
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br Introduction Glucose homeostasis is primarily regulated
2022-08-22
Introduction Glucose homeostasis is primarily regulated by the hormones insulin and glucagon, secreted from the pancreatic islets of Langerhans. Although insulin produced by β WIN 18446 is the blood glucose-lowering hormone, glucagon secreted from α cells acts as the major counter-regulatory hor
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Regarding IAV types of hemagglutinin and types
2022-08-19
Regarding IAV, 18 types of hemagglutinin and 11 types of neuraminidase were described and none of the commercialized antiviral drugs are susceptible to protect against all strains that will emerge from the animal reservoir (Webby and Webster, 2003). The strong dependencies of influenza viruses on we
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Several transgenic and knockout congenic mouse
2022-08-19
Several transgenic and knockout/congenic mouse models have been generated in order to assess the role of FFAR1 for proper insulin secretion and maintenance of glucose homeostasis. The results obtained with three different receptor knockout mouse models were not consistent. The protection against hig
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It raises a question about origin of the sensitivity to
2022-08-19
It raises a question about origin of the sensitivity to Ca of both FBPase isozymes. Was the ancestral vertebrate FBPase inhibited by calcium similarly to the liver isozyme? And is the high sensitivity of FBP2 a new evolutionary feature of warm-blooded vertebrates? Additionally, since subcellular lo
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Several classes of small molecule inhibitors of FBPase have
2022-08-19
Several 5,7-dihydroxychromone of small-molecule inhibitors of FBPase have been reported. These inhibitors can be structurally classified into two groups; non-phosphorus-based inhibitors and phosphorus-based inhibitors. In the former group, several chemotypes including anilinoquinazoline, indole dic
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br Methods and materials br
2022-08-19
Methods and materials Results Discussion In this study we demonstrate that CF epithelial Lomustine exhibit features of apoptosis in their basal, unstimulated state including increased caspase (-3 and -8) activation compared to non-CF epithelial cells. Analysis of factors responsible for th
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A large body of evidence supports
2022-08-19
A large body of evidence supports a contribution of the endocannabinoid (eCB) system in the regulation of stress and emotional behavior (Gorzalka and Hill, 2011, Hill and Patel, 2013, Morena et al., 2016). General findings from this work indicate that eCB anandamide signaling is critical for bufferi
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br Conclusion In conclusion our results demonstrate that
2022-08-19
Conclusion In conclusion, our results demonstrate that incubation of both LAD and SCA rat coronary arteries rapidly increases the ETB receptor-mediated contraction as well as upregulation of ETB receptor protein levels. These findings may have important experimental implications in tissue bath ex
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