• The synthetic route to M

  2023-08-30

  

  The synthetic route to M100907 developed by Rice was utilized, however, the chiral resolution was carried out at an earlier stage to provide the possibility of introducing different substituents onto the piperidinyl group. The conditions for this resolution were different from previously reported.

• Moreover our present work suggests that AXL

  2023-08-30

  

  Moreover, our present work suggests that AXL could be a modulator of sunitinib response, at least for cell lines that present high endogenous levels of this RTK activation, since we observed an increased responsiveness to sunitinib in EGFR Inhibitor activated with AXL receptor ligand. A role for AXL

• To identify the kinase s mediating

  2023-08-30

  

  To identify the kinase(s) mediating H3.3S31 phosphorylation, we devised a 96-well-plate-compatible immunostaining assay, with angiotensin ii specific for H3.3S31ph, and utilized it to screen both a Qiagen siRNA library covering 720 human kinases and a kinase inhibitor library (Selleck) containing 19

• The compounds containing beryllium act

  2023-08-30

  

  The compounds containing beryllium act as strong Lewis acids because of electron deficiency of the Be vasopressin receptor antagonists []. Interactions of X-Be-Y compounds with different Lewis bases have been studied by Yanez and co-workers [], extensively. Recently, they proposed a class of extrem

• Apelin APJ triggers a variety

  2023-08-30

  

  Apelin/APJ triggers a variety of cellular signaling pathways (Fig. 1). Recent studies from our laboratory showed that apelin-13 induces vascular smooth muscle cell (VSMC) proliferation by the upregulation of Cyclin D1 expression, which is involved in an ERK-dependent activation of Jagged-1/Notch3 si

• br The role of apelin in respiratory diseases

  2023-08-30

  

  The role of apelin in respiratory diseases At present, several scientific studies have suggested that the apelin/APJ system may play an important role in the development of pulmonary diseases (Table 4). For example, in an experiment on rats suffering from acute lung injury, apelin-13 decreases th

• br HMG proteins mobile modulators of chromatin structure

  2023-08-30

  

  HMG proteins: mobile modulators of chromatin structure and cellular phenotype The term “High Mobility Group” was originally coined for the HMG proteins because of their unusual solubility properties, their small size and their rapid mobility, relative to other chromatin proteins, during gel elect

• br Acknowledgments br Protein microarrays were developed to

  2023-08-30

  

  Acknowledgments Protein microarrays were developed to provide miniaturized high-throughput tools to study protein function, folate analogue and post-translational modifications. Just a few years ago, the seminal work performed in Stuart Schreiber's laboratory at Harvard University () and at Mic

• br Experimental procedures br Results br

  2023-08-30

  

  Experimental procedures Results Discussion Our biophysical and cellular analyses of mutant Aβ1–42 peptides support a role of the N-terminus of Aβ in peptide aggregation and toxicity. We demonstrate that double mutations constructed to humanize the rodent Aβ1–42 sequence result in a signific

• To date defining the prognostic impact of molecular

  2023-08-30

  

  To date, defining the prognostic impact of molecular drivers of early-stage NSCLC has been challenging due to the relative rarity of these subsets and the redefinition of comparator arms over time as understanding of the molecular drivers of NSCLC evolved. Indeed, use of molecularly heterogeneous co

• Blocking the action of CREB with the

  2023-08-30

  

  Blocking the action of CREB with the C646 inhibitor together with increasing Akt activation with the SC79 agonist is particularly interesting as it significantly reduced wound closure time from 7 days (which is required for complete closure of control hTECs exposed to DMSO) to only 4 days (when hTEC

• br Endocytosis of AdipoR Surface receptor activity

  2023-08-30

  

  Endocytosis of AdipoR1 Surface receptor activity may be shut down by endocytic uptake and subsequent lysosomal degradation of the proteins [20]. Clathrin-dependent endocytosis (CDE) has been extensively studied and internalization from the plasma membrane is mediated through clathrin-coated pits

• Adenosine A A agonists have

  2023-08-29

  

  Adenosine A2A agonists have been shown to significantly reduce albuminuria in diabetic mice as well as plasma creatinine [24]. Proteinuria was greater in diabetic A2A knock-out (KO) mice than diabetic wild type (WT) mice [24]. Consistent with these findings, our laboratory initially found that prote

• The first result of this

  2023-08-29

  

  The first result of this paper is parallel to the positivity result given in [16]: Here the definition of approximate ACHE metric is the same as in [18]. See Definition 1 for details. The second result of this paper is parallel to the Papain extension formulae given in [2]. In particular, while is

• HCC aetiology is multifactorial and the disease is often

  2023-08-29

  

  HCC aetiology is multifactorial and the disease is often preceded by other conditions including liver fibrosis and cirrhosis that are associated with HCV, HBV, alcoholic and non-alcoholic hepatitis. The discovery of new therapeutic targets will require a greater understanding of the pathogenic mecha

14738 records 275/983 page Previous Next First page 上5页 271272273274275 下5页 Last page