• Numerous studies have reported high glutamate levels in the

  2024-06-19

  

  Numerous studies have reported high glutamate levels in the brains of patients with depression, indicating that the glutamate system plays a crucial role in depression (Sanacora et al., 2004; Kendell et al., 2005; Hashimoto et al., 2007). Furthermore, several clinically effective antidepressant drug

• Mistletoe is universal name for various species

  2024-06-18

  

  Mistletoe is universal name for various species of parasitic plant which grows attached to and within the branches of host trees such as apple, elm, oak and pine. Mistletoe extract prepared from Viscum album, a species of mistletoe in the family Santalaceae, is generally known as European mistletoe

• The class C receptors also share a common agonist binding

  2024-06-18

  

  The class C receptors also share a common agonist-binding mode. In all cases, an agonist induces VFT closure by forming intermolecular bonds with surface residues in both the LB1 and LB2 domains (Geng et al., 2013, Geng et al., 2016, Kunishima et al., 2000, Muto et al., 2007, Nuemket et al., 2017, T

• Thymoquinone TQ is the major active

  2024-06-18

  

  Thymoquinone (TQ) is the major active Ro 60-0175 fumarate derived from Nigella sativa (Woo et al., 2012). Recent animal studies support the potential of TQ for the treatment of a variety of inflammatory disorders like inflammatory bowel disease (IBD), RA, and osteoarthritis (OA) (Salem, 2005, Badr e

• TLX may promote survival and prevent apoptosis in NB cells

  2024-06-18

  

  TLX may promote survival and prevent apoptosis in NB nk1 antagonist [12]. Here, we ask whether the survival-promoting effects of TLX are mediated by Apoptosis Signal-regulating Kinase-1 (ASK1, MAP3K5). ASK1 is a member of the Mitogen-Activated Protein (MAP) kinase family and it preferentially activa

• Previous investigations have established that aromatase acti

  2024-06-18

  

  Previous investigations have established that aromatase activity is regulated via two different pathways in a tissue-specific manner. The first is a slower transcription regulatory pathway that involves an alteration in gene transcription and represents what is classically thought of as the way by w

• br Materials and methods br Results

  2024-06-18

  

  Materials and methods Results Discussion Japanese encephalitis caused by JEV is characterized by 2536 neuron death. However, the underlying mechanism is not fully understood. We and other researchers have demonstrated that JEV induces apoptosis by ER stress-mediated IRE1/JNK and ROS-mediat

• (±)-J 113397 Mechanistically it was soon realized

  2024-06-18

  

  Mechanistically, it was soon realized that in undead cells, Dronc promotes the activation of Jun-N-terminal kinase (JNK) signaling as the major inducer of AiP [25], [28] (Fig. 2B,C). However, it has been unknown for a long time how active Dronc promotes JNK signaling. Recently, it was reported that

• br Conclusion br References and recommended reading Papers o

  2024-06-18

  

  Conclusion References and recommended reading Papers of particular interest, published within the period of review, have been highlighted as: Acknowledgements Introduction Nucleosome, the basic chromatin unit, is composed of DNA and core histones (H2A, H2B, H3 and H4) and organized into

• The renin angiotensin system RAS is a

  2024-06-18

  

  The renin-angiotensin system (RAS) is a hormonal system which plays a role in the regulation of blood pressure and body fluid VU 0155069 sale [14]. The main bioactive peptide of RAS is angiotensin II (Ang II) whose biological functions are interposed through angiotensin type 1 receptor (AT1R) and an

• br Alzheimer s disease AD is an irreversible

  2024-06-18

  

  Alzheimer’s disease (AD) is an irreversible, age-associated neurodegenerative disorder that is characterized by progressive memory loss and cognitive decline. AD is also the leading cause of dementia, accounting for 5 million cases in the United States and 44 million cases worldwide. In 2015, AD c

• br Perspective AA LA and other PUFAs

  2024-06-18

  

  Perspective AA, LA and other PUFAs and their lipid metabolites play an important role in human diseases. 12/15-LOX which is the metabolic enzyme of them plays an important role in the pathogenesis-related diseases such as atherosclerosis, diabetic nephropathy, neurological diseases and other path

• The fat body is one of the

  2024-06-18

  

  The fat body is one of the largest tissues of Bombyx mori, with components including fat, glycogen, protein and vitamins. The fat body exhibits important physiological functions, not only storing a large number of nutrients but also serving as an important site of biosynthesis and metabolism (Arrese

• It thus appeared reasonable that

  2024-06-18

  

  It thus appeared reasonable that AR needed to be inhibited and great experimental efforts began which are still on-going [6]. Indeed, hundreds of ARIs have been characterized but no significant drug development has followed. The case of Sorbinil, which did not pass clinical trials is emblematic [7]

• Active SI behavior was dose dependently affected

  2024-06-17

  

  Active SI behavior was dose-dependently affected by PACAP treatment (F3,25 = 14.42, p 2-Cl-IB-MECA synthesis 1 week later (F3,20 = 8.93, p hypothesis that PACAP causes disruptions in posterror adjustments that are similar to disruptions seen in humans with depression.

14738 records 127/983 page Previous Next First page 上5页 126127128129130 下5页 Last page